Research interests

 
 


Dr Bogari interests are in the role of genetics and multifactorial Disease focus in Gene-environment interactions in the developmental disease.


Cardiovascular


He obtained his PhD between 2002 and 2008 at the University of Southampton in Cardiovascular Genetics since then, Over that period he feels he has made a valuable contribution to the study of heart diseases as well as multifactorial/ polygenic disorders. His focus has been the study of genes involved in lipid metabolism by collaborating with Monzino Heart Center, Milan, Italy (Professor Franceco Alamanni),  King Fahd Armed Forces Hospital in Jeddah, and King Abdullah Medical City in Makkah(Dr Massimo  Porqueddu), we studied ABCA1, Apolipoprotein B and A5 genes, LPL and other variant.


Special education needs


It is believed that genetics is the major role of special education needs and disabilities. With (Dr Nermeen Qutub), he studied the genomic variant effect on ADHD, Autism with (Professor Elhawary N and Professor Tayeb MT), Dyslexia, and intellectual disability. Correlations we studied involved the interaction between genetic, endocrine, and behavioral symptoms in these diseases.


Allergy


This study was funded by the National Plan for Science, Technology, and Innovation (MAARIFAH)-King Abdulaziz City for Science and Technology-the kingdom of Saudi Arabia, award number (13-BIO890-10) and collaborated with Maternity Children Hospital Makkah (Dr Hosni H Raies)


Asthma study In collaboration with colleagues at the University of Southampton, UK  (Professor John Holloway) we are studying the pediatric asthma in Saudi Arabia by using Next generation sequencing, also, he studied Eczema and food allergy with (Professor Faisal Al-Allaf ) and King Saud University in Riyadh(Professor Khalid K Alharbi)



Acute Kidney Injury


AKI is common in critically ill children admitted to pediatric and in adult in resent years has significantly increased mortality in Saudi Arabia, Dr N Bogari and Dr Amr Ahmed Amin are interested in studying the genomic and biochemistry of the cause of the disease. This study will help the early detection and prevention of the disease. The molecular genetic investigations will perform through two approaches: 1st approach is genome-wide association study (GWAS) for screening the whole genes in the AKI and the 2nd approach is candidate genes association study for selected genes related to alterations in AKI disorder.




Epilepsy


This research is running in collaboration with colleagues at maternity hospital in Makkah(Dr Abeer Matter), and ST George`s University of London well Neuro Centre (Dr Anan Shtaya).  It is reported that epilepsy is caused by genetic and environmental factors. Our plan is an Epilepsy Pheno-genomic proposal with a multi-reigonal, retrospective phenotype–genotype study designed to gather and analyze detailed phenotypic information and genetic variations for DNA samples on suitable participants. we are interested in identifying possible novel biomarkers from interactions between both studies geneticals and biochemical this  can present clinical trials of new drugs in the treatment of epilepsy and  genetic panels was a necessity to diagnose various

forms of epilepsy. 

Research interests